Onycholysis secondary to multiple paclitaxel 1-hour infusions: possible role for its vehicle (Cremophor EL)
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چکیده
منابع مشابه
Onycholysis secondary to multiple paclitaxel 1-hour infusions: possible role for its vehicle (Cremophor EL).
anastrozole for 10 weeks; after 4 weeks they received quinapril for 28 days; blood samples were taken at the same time as group A. Blood pressure was measured at the time of entry, before starting quinapril and twice a day during the 4 weeks of treatment with ACE inhibitor. Primary assessment was the steady-state plasma anastrozole concentrations following once-daily anastrozole alone or anastr...
متن کاملCremophor pharmacokinetics in patients receiving 3-, 6-, and 24-hour infusions of paclitaxel.
BACKGROUND Paclitaxel (Taxol) is a new drug with efficacy against a variety of malignant tumors. The clinical formulation of paclitaxel contains 50% Cremophor EL, a polyethoxylated castor oil vehicle (carrier) that can reverse multidrug resistance (MDR) mediated by P-glycoprotein. Three-hour intravenous infusions of paclitaxel can yield end-of-infusion plasma Cremophor concentrations of 1 micro...
متن کاملInfluence of formulation vehicle on metronomic taxane chemotherapy: albumin-bound versus cremophor EL-based paclitaxel.
PURPOSE Low-dose metronomic chemotherapy treatments, especially when combined with 'dedicated' antiangiogenic agents, can induce significant antitumor activity without serious toxicity in various preclinical models. It remains unclear, however, whether some cytotoxic drugs are better suited for metronomic regimens than others. Paclitaxel appears to be a strong candidate for metronomic chemother...
متن کاملInfluence of Cremophor El on the bioavailability of intraperitoneal paclitaxel.
It has been hypothesized that the paclitaxel vehicle Cremophor EL (CrEL) is responsible for nonlinear drug disposition by micellar entrapment. To gain further insight into the role of CrEL in taxane pharmacology, we studied the pharmacokinetics of paclitaxel in the presence and absence of CrEL after i.p. and i.v. dosing. Patients received an i.p. tracer dose of [G-(3)H]paclitaxel in ethanol wit...
متن کاملSuspected anaphylactic reaction to Cremophor EL.
There have been several reports of anaphylactoid reactions to the intravenous anaesthetic drugs Althesin (alphaxalone and alphadolone) and propanidid (Epontol).' The culprit in some of these reactions may have been Cremophor EL, a surfactant common to both drug formulations. Cremophor EL is produced by the epoxylation of castor oil and is actually a complex mixture of compounds. We report a cas...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2003
ISSN: 0923-7534
DOI: 10.1093/annonc/mdg419